Glutamatergic agents for schizophrenia: current evidence and perspectives

@article{Zink2015GlutamatergicAF,
  title={Glutamatergic agents for schizophrenia: current evidence and perspectives},
  author={Mathias Zink and Christoph U. Correll},
  journal={Expert Review of Clinical Pharmacology},
  year={2015},
  volume={8},
  pages={335 - 352}
}
  • M. Zink, C. Correll
  • Published 28 April 2015
  • Psychology, Medicine
  • Expert Review of Clinical Pharmacology
Suboptimal outcomes in schizophrenia are a consequence of lacking insight into the etiology, biomarkers and treatment-relevant subgroups, the therapeutic restriction to dopaminergic-modulating antipsychotics that fail to significantly improve negative and cognitive symptoms, non-adherence, and, in the case of treatment-resistance, the underutilization of clozapine. Evidence suggests additional, extra-dopaminergic abnormalities in amino acid neurotransmission, particularly the glutamatergic… 
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