Glutamatergic Synaptic Dysfunction and Obsessive-Compulsive Disorder

  title={Glutamatergic Synaptic Dysfunction and Obsessive-Compulsive Disorder},
  author={Jonathan T. Ting and Guoping Feng},
  booktitle={Current chemical genomics},
Obsessive-compulsive disorder (OCD) is a debilitating neuropsychiatric condition estimated to afflict 1-3% of the world population. The estimated financial impact in the treatment and management of OCD is in the billions of dollars annually in the US alone. At present there is a marked lack of evidence on the specific causes of OCD. Current hypotheses largely focus on the serotonin (5-HT) system on the basis of the effectiveness of selective serotonin reuptake inhibitors (SSRIs) in alleviating… CONTINUE READING
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