Glutamate uptake system in the presynaptic vesicle: Glutamic acid analogs as inhibitors and alternate substrates

Abstract

A variety of naturally occurring amino acids, their isomers, and synthetic analogs were tested for their ability to inhibit uptake of [3H]glutamate into presynaptic vesicles from bovine cerebral cortex. Strongest inhibition (Ki<1mM) was observed fortrans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) anderythro-4-methyl-L-glutamic acid (MGlu), while 4… (More)
DOI: 10.1007/BF00966925

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