Glutamate uptake impairment and neuronal damage in young and aged rats in vivo.

@article{Massieu1997GlutamateUI,
  title={Glutamate uptake impairment and neuronal damage in young and aged rats in vivo.},
  author={Lourdes Massieu and Ricardo Tapia},
  journal={Journal of neurochemistry},
  year={1997},
  volume={69 3},
  pages={1151-60}
}
The extracellular concentration of glutamate increases during hypoxia/ischemia probably due to deficient uptake. Glutamate might contribute to neuronal damage associated with this disorder and to neurodegeneration during aging. In the present study, we have tested the effect of two inhibitors of glutamate transport, L-trans-pyrrolidine-2,4-dicarboxylate and dihydrokainate, on the extracellular levels of glutamate and on neuronal damage, which was quantitatively studied by image analysis of… CONTINUE READING

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