Glutamate uptake from the synaptic cleft does not shape the decay of the non-NMDA component of the synaptic current.

@article{Sarantis1993GlutamateUF,
  title={Glutamate uptake from the synaptic cleft does not shape the decay of the non-NMDA component of the synaptic current.},
  author={M. E. P. Sarantis and Laura Ballerini and Barbara N Miller and R. Angus Silver and Mark Edwards and David Attwell},
  journal={Neuron},
  year={1993},
  volume={11 3},
  pages={541-9}
}
To study the role of glutamate uptake at central glutamatergic synapses, we used the uptake blocker L-transpyrrolidine-2,4-dicarboxylate (PDC). The effects of PDC on the glutamate uptake current in salamander retinal glia indicated that PDC competes with glutamate for transport on the uptake carrier and that 300 microM PDC should significantly reduce the uptake of glutamate during the synaptic current. In isolated rat hippocampal neurons, 300 microM PDC did not affect non-N-methyl-D-aspartate… CONTINUE READING
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