Glutamate transporters regulate extrasynaptic NMDA receptor modulation of Kv2.1 potassium channels.

@article{Mulholland2008GlutamateTR,
  title={Glutamate transporters regulate extrasynaptic NMDA receptor modulation of Kv2.1 potassium channels.},
  author={Patrick J. Mulholland and Ezekiel P Carpenter-Hyland and Matthew C Hearing and Howard C Becker and John J Woodward and L Judson Chandler},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2008},
  volume={28 35},
  pages={8801-9}
}
Delayed-rectifier Kv2.1 potassium channels regulate somatodendritic excitability during periods of repetitive, high-frequency activity. Recent evidence suggests that Kv2.1 channel modulation is linked to glutamatergic neurotransmission. Because NMDA-type glutamate receptors are critical regulators of synaptic plasticity, we investigated NMDA receptor modulation of Kv2.1 channels in rodent hippocampus and cortex. Bath application of NMDA potently unclustered and dephosphorylated Kv2.1 and… CONTINUE READING
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