Glutamate transporters in neurologic disease.


The neurotoxic properties of glutamate were first demonstrated in 1957 by Lucas and Newhouse, who showed that systemic administration of glutamate to infant mice caused retinal degeneration. Over the last 4 decades, a direct correlation between the neuroexcitatory and neurotoxic properties of glutamate has been linked to activation of excitatory amino acid… (More)


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@article{Maragakis2001GlutamateTI, title={Glutamate transporters in neurologic disease.}, author={Nicholas J. Maragakis and Joseph Rothstein}, journal={Archives of neurology}, year={2001}, volume={58 3}, pages={365-70} }