Glutamate transporters bring competition to the synapse

  title={Glutamate transporters bring competition to the synapse},
  author={Y. Huang and D. Bergles},
  journal={Current Opinion in Neurobiology},
  • Y. Huang, D. Bergles
  • Published 2004
  • Biology, Medicine
  • Current Opinion in Neurobiology
  • Glutamate transporters (GluTs) prevent the accumulation of glutamate and influence the occupancy of receptors at synapses. The ability of extrasynaptic NMDA receptors and metabotropic glutamate receptors to participate in signaling is tightly regulated by GluT activity. Astrocytes express the highest density of GluTs and dominate clearance away from these receptors; synapses that are not associated with astrocyte processes experience greater mGluR activation and can be exposed to glutamate… CONTINUE READING
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