Glutamate transporters bring competition to the synapse

@article{Huang2004GlutamateTB,
  title={Glutamate transporters bring competition to the synapse},
  author={Y. Huang and D. Bergles},
  journal={Current Opinion in Neurobiology},
  year={2004},
  volume={14},
  pages={346-352}
}
  • Y. Huang, D. Bergles
  • Published 2004
  • Biology, Medicine
  • Current Opinion in Neurobiology
  • Glutamate transporters (GluTs) prevent the accumulation of glutamate and influence the occupancy of receptors at synapses. The ability of extrasynaptic NMDA receptors and metabotropic glutamate receptors to participate in signaling is tightly regulated by GluT activity. Astrocytes express the highest density of GluTs and dominate clearance away from these receptors; synapses that are not associated with astrocyte processes experience greater mGluR activation and can be exposed to glutamate… CONTINUE READING
    265 Citations
    Surface diffusion of astrocytic glutamate transporters shapes synaptic transmission
    • 154
    • PDF
    Molecular and cellular physiology of sodium-dependent glutamate transporters
    • 36
    Bidirectional neuron-glia interactions triggered by deficiency of glutamate uptake at spinal sensory synapses.
    • 25
    • PDF
    Acute regulation of sodium-dependent glutamate transporters: a focus on constitutive and regulated trafficking.
    • M. B. Robinson
    • Medicine, Biology
    • Handbook of experimental pharmacology
    • 2006
    • 73
    • Highly Influenced
    Astrocyte and Neuron Intone Through Glutamate
    • 20
    • PDF
    Astrocytic group I mGluR-dependent potentiation of astrocytic glutamate and potassium uptake.
    • 46
    • PDF

    References

    SHOWING 1-10 OF 67 REFERENCES
    Synaptic Activation of Glutamate Transporters in Hippocampal Astrocytes
    • 478
    Neuronal Glutamate Transporters Limit Activation of NMDA Receptors by Neurotransmitter Spillover on CA1 Pyramidal Cells
    • J. Diamond
    • Biology, Medicine
    • The Journal of Neuroscience
    • 2001
    • 251
    • PDF
    Flux coupling in a neuronal glutamate transporter
    • 753
    Cooperation between independent hippocampal synapses is controlled by glutamate uptake
    • 227
    • PDF
    Glutamate uptake
    • 2,549
    Neuronal Glutamate Uptake Contributes to GABA Synthesis and Inhibitory Synaptic Strength
    • 196
    • PDF
    Block of glutamate transporters potentiates postsynaptic excitation
    • 343
    Substrate Turnover by Transporters Curtails Synaptic Glutamate Transients
    • 101
    • PDF