Glutamate transporters: animal models to neurologic disease

@article{Maragakis2004GlutamateTA,
  title={Glutamate transporters: animal models to neurologic disease},
  author={Nicholas J. Maragakis and Jeffrey D Rothstein},
  journal={Neurobiology of Disease},
  year={2004},
  volume={15},
  pages={461-473}
}
Glutamate is the primary excitatory amino acid neurotransmitter in the central nervous system and its activity is carefully modulated in the synaptic cleft by glutamate transporters. A number of glutamate transporters have been identified in the central nervous system and each has a unique physiologic property and distribution. Glutamate transporter dysfunction may either be an initiating event or part of a cascade leading to cellular dysfunction and ultimately cell death. Animal models of… CONTINUE READING

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