Glutamate transporter and receptor function in disorders of ammonia metabolism.

  title={Glutamate transporter and receptor function in disorders of ammonia metabolism.},
  author={Roger F. Butterworth},
  journal={Mental retardation and developmental disabilities research reviews},
  volume={7 4},
Disorders of ammonia metabolism including urea cycle enzymopathies, Reye Syndrome, and liver failure are associated with brain edema and severe neurological impairment. Excess blood-borne ammonia crosses the blood-brain barrier by diffusion as NH(3) where it interacts with various cellular processes involved in neurotransmission and brain energy metabolism. Ammonia exerts a potent effect on glutamate (AMPA) receptor-mediated neurotransmission. Ammonia also inhibits high affinity transport of… CONTINUE READING


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