Glutamate transport, glutamine synthetase and phosphate-activated glutaminase in rat CNS white matter. A quantitative study.

@article{Hassel2003GlutamateTG,
  title={Glutamate transport, glutamine synthetase and phosphate-activated glutaminase in rat CNS white matter. A quantitative study.},
  author={Bj\ornar Hassel and Karen Astrid Boldingh and Cecilie Narvesen and Evy Grini Iversen and Knut Kristian Skrede},
  journal={Journal of neurochemistry},
  year={2003},
  volume={87 1},
  pages={230-7}
}
Glutamatergic signal transduction occurs in CNS white matter, but quantitative data on glutamate uptake and metabolism are lacking. We report that the level of the astrocytic glutamate transporter GLT in rat fimbria and corpus callosum was approximately 35% of that in parietal cortex; uptake of [3H]glutamate was 24 and 43%, respectively, of the cortical value. In fimbria and corpus callosum levels of synaptic proteins, synapsin I and synaptophysin were 15-20% of those in cortex; the activities… CONTINUE READING

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