Glutamate stimulates inositol phosphate formation in striatal neurones

@article{Sladeczek1985GlutamateSI,
  title={Glutamate stimulates inositol phosphate formation in striatal neurones},
  author={Fritz Sladeczek and Jean-Philippe Pin and Max R{\'e}casens and Jo{\"e}l Bockaert and Samuel Weiss},
  journal={Nature},
  year={1985},
  volume={317},
  pages={717-719}
}
The major excitatory amino acids, glutamate (Glu) and aspartate (Asp), are thought to act at three receptor subtypes1 in the mammalian central nervous system (CNS). These are termed quisqualate (QA), N-methyl-D-aspartate (NMDA) and kainate (KA) receptors according to the specific agonist properties of these compounds revealed by electrophysiological studies1,2. Although Glu has been shown to stimulate cyclic GMP formation in brain slices3, direct regulation of second messenger systems (cyclic… Expand
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The production of inositol phosphate from tritiated inositl was studied in striatal slices of neonatal rats and the receptor mediating the inhibitory response to N-methylaspartate appears pharmacologically similar to the NMDA-preferring receptor defined electrophysiologically. Expand
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In conclusion, excitatory amino acids appear to reduce agonist‐mediated inositol phosphate formation in rat cerebral cortex by a non‐specific action, possibly including the influx of Na+ ions. Expand
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The studies provide evidence that ionotropic and not metabotropic glutamate receptors are involved in PI metabolism in the retina and show CARB and KA to be the most effective in stimulating the production of IPs. Expand
A new quisqualate receptor subtype (sAA2) responsible for the glutamate-induced inositol phosphate formation in rat brain synaptoneurosomes
TLDR
The results provide the first pharmacological evidence indicating that a new quisqualate receptor subtype, tentatively termed sAA(2) is responsible for inositol phosphate formation. Expand
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Depression of APV-resistant spinal transmission by PDA and synaptically localized kainate binding in the hippocampus suggest that kainates and/or quisqualate receptors are also involved in excitatory transmission. Expand
Characterization of the excitatory amino acid receptor-mediated release of [3H]acetylcholine from rat striatal slices
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The results suggest that excitatory amino acids act at receptors on the dendrites of striatal cholinergic interneurons, giving rise to action potentials and release of acetylcholine from Cholinergic nerve terminals. Expand
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  • Proceedings of the National Academy of Sciences of the United States of America
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TLDR
The results demonstrate that L-glutamate binding sites may be resolved into three distinct subtypes (categories A1, A2, and A4), each corresponding to an electrophysiologically identified receptor class, and that the N-methyl aspartate and quisqualate receptor types are selectively associated with PSDs. Expand
The differential effects of excitatory amino acids on uptake of 45CaCl2 by slices from mouse striatum
TLDR
The results suggest that glutamate may activate a receptor directly linked to Ca2+ channels, whereas kainate may indirectly modulate the intracellular disposition of Ca2+. Expand
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TLDR
An accumulation of 3H-labelled inositol phosphates is observed when prelabelled rat superior cervical sympathetic ganglia are exposed to [8-arginine]vasopressin or to muscarinic cholinergic stimuli, suggesting that the initiating reaction in stimulated inositl lipid metabolism is a phosphodiesterase-catalysed hydrolysis of phosphatidylinositol 4,5-bisphosphate. Expand
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TLDR
The results show that different receptors mediating phosphatidylinositol/ polyphosphoinositide breakdown in rat cortex have quantitatively different Ca2+ requirements, and it is suggested that rigid opinions regarding phosph atidyl inositol / polyph phospholipid breakdown as either cause or effect of calcium mobilisation in rat cerebral cortex are inappropriate. Expand
Stimulated formation of cyclic adenosine 3':5'-monophosphate by aspartate and glutamate in cerebral cortical slices of guinea pig.
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The amino acids tested suggest that the amino acids may be a new class of stimulants which is different from biogenic amines, adenosine, and depolarizing agents as stimulants for cyclic AMP formation in incubated brain slices. Expand
Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides.
TLDR
The results suggest that the earliest event in the stimulus-response pathway is the hydrolysis of polyphosphoinositides by a phosphodiesterase to yield inositol 1,4,5-trisphosphate and inositl 1, 4-bisph phosphate, which are subsequently hydrolysed to inositoli 1-phosphates and inposol. Expand
Agonist-induced myopathy at the neuromuscular junction is mediated by calcium
TLDR
The results favor the hypothesis that esterase inhibition leads to an agonist-induced myopathy, which is mediated by Ca++ and requires an intact AChR, and could be prevented by inactivating the acetylcholine receptors with alpha- bungarotoxin or by removing Ca++ from the bath with EGTA. Expand
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