Glutamate spillover drives endocannabinoid production and inhibits GABAergic transmission in the Substantia Nigra pars compacta.

@article{Freestone2014GlutamateSD,
  title={Glutamate spillover drives endocannabinoid production and inhibits GABAergic transmission in the Substantia Nigra pars compacta.},
  author={Peter S. Freestone and Ezia Guatteo and Fabiana Piscitelli and Vincenzo Di Marzo and Janusz Lipski and Nicola Biagio Mercuri},
  journal={Neuropharmacology},
  year={2014},
  volume={79},
  pages={467-75}
}
Endocannabinoids (eCBs) modulate synaptic transmission in the brain, but little is known of their regulatory role in nigral dopaminergic neurons, and whether transmission to these neurons is tonically inhibited by eCBs as seen in some other brain regions. Using whole-cell recording in midbrain slices, we observed potentiation of evoked IPSCs (eIPSCs) in these neurons after blocking CB1 receptors with rimonabant or LY-320,135, indicating the presence of an eCB tone reducing inhibitory synaptic… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 68 references

Differential subcellular localization of mGluR1a and mGluR5 in the rat and monkey Substantia nigra.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2001
View 6 Excerpts
Highly Influenced

30-carbamoyl-biphenyl-3-yl ester (URB597): effects on anandamide and oleoylethanolamide deactivation

C. C. Felder, K. E. Joyce, +9 authors M. Brownstein
J. Pharmacol. Exp. Ther • 1998
View 4 Excerpts
Highly Influenced

The biosynthesis of N-arachidonoyl dopamine (NADA), a putative endocannabinoid and endovanilloid, via conjugation of arachidonic acid with dopamine

Hu, S.S.-J, +12 authors J. M. Walker
Prostag. Leukotr. Essential Fatty Acids • 2009
View 5 Excerpts
Highly Influenced

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