Glutamate signaling in chondrocytes and the potential involvement of NMDA receptors in cell proliferation and inflammatory gene expression.

@article{Piepoli2009GlutamateSI,
  title={Glutamate signaling in chondrocytes and the potential involvement of NMDA receptors in cell proliferation and inflammatory gene expression.},
  author={Tiziana Piepoli and Laura Mennuni and Silvia Zerbi and Mario Lanza and LucioC. Rovati and Gianfranco Caselli},
  journal={Osteoarthritis and cartilage},
  year={2009},
  volume={17 8},
  pages={
          1076-83
        }
}
OBJECTIVE Increased levels of glutamate, the main excitatory neurotransmitter, are found in the synovial fluid of osteoarthritis (OA) patients. Our aim was to study glutamate signaling in chondrocytes, focusing on the composition, pharmacology, and functional role of N-methyl-d-aspartate (NMDA) glutamate receptors. METHODS We used the human chondrocyte cell line SW1353 and, in parallel, primary rat articular chondrocytes. Glutamate release and uptake were measured by fluorimetric and… CONTINUE READING
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