Glutamate release inhibitors: A critical assessment of their action mechanism

Abstract

A number of important experimental data do not support the widespread hypothesis that Na+-channels block is cerebroprotective, essentially because it reduces presynaptic glutamate release: (i) the inhibition of exocytosis by these compounds is not specific to glutamate; (ii) aspartate efflux produced by various stimuli was also reduced, but aspartate cannot… (More)
DOI: 10.1007/BF01345255

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