Glutamate release in the nucleus tractus solitarius induced by peripheral lipopolysaccharide and interleukin-1 beta.

@article{Mascarucci1998GlutamateRI,
  title={Glutamate release in the nucleus tractus solitarius induced by peripheral lipopolysaccharide and interleukin-1 beta.},
  author={Paolo Mascarucci and Carlo Perego and Salvatore Terrazzino and Maria-Grazia De Simoni},
  journal={Neuroscience},
  year={1998},
  volume={86 4},
  pages={1285-90}
}
The involvement of vagal afferents in the communication pathway from the immune system to the brain was studied. Glutamate was measured in the nucleus tractus solitarius, the brain area receiving glutamatergic vagal afferents, after peripheral injection of lipopolysaccharide or interleukin-1 beta. Intraperitoneal or intravenous saline or intraperitoneal heat-inactivated interleukin-1 beta increased glutamate release, measured by brain microdialysis in freely-moving rats at 20 min (137 +/- 19… CONTINUE READING