Glutamate release during LTD at cerebellar climbing fiber–Purkinje cell synapses

  title={Glutamate release during LTD at cerebellar climbing fiber–Purkinje cell synapses},
  author={Ying Shen and Christian R W Hansel and David E. J. Linden},
  journal={Nature Neuroscience},
It is widely thought that persistent, use-dependent alterations in synaptic strength such as long-term synaptic potentiation (LTP) and depression (LTD) underlie at least a portion of memory traces in the brain, but the exact cellular locus of expression for these alterations remains to be determined. They could be expressed presynaptically as a decrease in transmitter release, postsynaptically as a decrease in the synaptic current evoked by a fixed delivery of transmitter, as an increase in the… CONTINUE READING
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