Glutamate regulates IP3-type and CICR stores in the avian cochlear nucleus.

@article{Kato1999GlutamateRI,
  title={Glutamate regulates IP3-type and CICR stores in the avian cochlear nucleus.},
  author={B Maya Kato and Edwin W. Rubel},
  journal={Journal of neurophysiology},
  year={1999},
  volume={81 4},
  pages={1587-96}
}
Neurons of the avian cochlear nucleus, nucleus magnocellularis (NM), are activated by glutamate released from auditory nerve terminals. If this stimulation is removed, the intracellular calcium ion concentration ([Ca2+]i) of NM neurons rises and rapid atrophic changes ensue. We have been investigating mechanisms that regulate [Ca2+]i in these neurons based on the hypothesis that loss of Ca2+ homeostasis causes the cascade of cellular changes that results in neuronal atrophy and death. In the… CONTINUE READING