Glutamate receptors of rod bipolar cells are linked to a cyclic GMP cascade via a G-protein.

@article{Shiells1990GlutamateRO,
  title={Glutamate receptors of rod bipolar cells are linked to a cyclic GMP cascade via a G-protein.},
  author={Richard Shiells and G U Falk},
  journal={Proceedings. Biological sciences},
  year={1990},
  volume={242 1304},
  pages={91-4}
}
Whole-cell patch-clamp recordings were obtained from light-responsive on-bipolar cells in retinal slices of the dogfish. Inclusion of the G-protein activator, GTP gamma S, in the intracellular patch solution mimicked the action of glutamate, inducing an increase in net outward current (interpreted as a decrease in inward current), a decrease in membrane conductance and block of light responses. Cyclic GMP (cGMP) in the patch pipette increased inward current and membrane conductance, and blocked… CONTINUE READING