Glutamate receptors in the rat medial prefrontal cortex regulate set-shifting ability.

@article{Stefani2003GlutamateRI,
  title={Glutamate receptors in the rat medial prefrontal cortex regulate set-shifting ability.},
  author={Mark Renato Stefani and Karyn M Groth and Bita Moghaddam},
  journal={Behavioral neuroscience},
  year={2003},
  volume={117 4},
  pages={728-37}
}
The authors examined set-shifting abilities in rats injected with antagonists of N-methyl-D-aspartate (NMDA) receptors (MK801) or alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors (LY293558) into the medial prefrontal cortex (mPFC). Set-shifting was assessed with a maze-based task requiring a switch between brightness and texture discrimination strategies. Intra-mPFC injection of MK801 prior to training on the 2nd discrimination impaired discrimination strategy… CONTINUE READING
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