Glutamate receptors at atomic resolution

@article{Mayer2006GlutamateRA,
  title={Glutamate receptors at atomic resolution},
  author={Mark L Mayer},
  journal={Nature},
  year={2006},
  volume={440},
  pages={456-462}
}
  • M. Mayer
  • Published 22 March 2006
  • Biology
  • Nature
At synapses throughout the brain and spinal cord, the amino-acid glutamate is the major excitatory neurotransmitter. During evolution, a family of glutamate-receptor ion channels seems to have been assembled from a kit consisting of discrete ligand-binding, ion-channel, modulatory and cytoplasmic domains. Crystallographic studies that exploit this unique architecture have greatly aided structural analysis of the ligand-binding core, but the results also pose a formidable challenge, namely that… 
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