Glutamate receptors as targets of protein kinase C in the pathophysiology and treatment of animal models of Mania

@article{Szabo2009GlutamateRA,
  title={Glutamate receptors as targets of protein kinase C in the pathophysiology and treatment of animal models of Mania},
  author={Steven T. Szabo and Rodrigo Machado-Vieira and Peixiong Yuan and Yun Wang and J Du},
  journal={Neuropharmacology},
  year={2009},
  volume={56},
  pages={47-55}
}
Considerable biochemical evidence suggests that the protein kinase C (PKC) signaling cascade may be a convergent point for the actions of anti-manic agents, and that excessive PKC activation can disrupt prefrontal cortical regulation of thinking and behavior. To date, however, brain protein targets of PKC's anti-manic effects have not been fully identified. Here we showed that PKC activity was enhanced in the prefrontal cortex of animals treated with the psychostimulant amphetamine… CONTINUE READING

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