Glutamate receptors and the regulation of steroidogenesis in the human adrenal gland: The metabotropic pathway

@article{Felizola2014GlutamateRA,
  title={Glutamate receptors and the regulation of steroidogenesis in the human adrenal gland: The metabotropic pathway},
  author={S. J. Felizola and Yasuhiro Nakamura and F. Satoh and R. Morimoto and K. Kikuchi and Tomohiro Nakamura and A. Hozawa and Lin Wang and Y. Onodera and Kazue Ise and K. McNamara and S. Midorikawa and Shin-ichi Suzuki and H. Sasano},
  journal={Molecular and Cellular Endocrinology},
  year={2014},
  volume={382},
  pages={170-177}
}
BACKGROUND l-glutamate is a major excitatory neurotransmitter in the mammalian brain. Glutamate receptors have been reported in the rat adrenal cortex and in human aldosterone-producing adenomas (APA). However, details regarding the expression levels and functions of these receptors in human adrenocortical tissues remain unknown. METHODS The mRNA levels of glutamate receptors were evaluated by qPCR in: 12 normal adrenal cortex (NAC), 11 APA, and 12 cortisol-producing adenoma (CPA) tissues… Expand
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