Glutamate receptors and the regulation of steroidogenesis in the human adrenal gland: The metabotropic pathway

  title={Glutamate receptors and the regulation of steroidogenesis in the human adrenal gland: The metabotropic pathway},
  author={Saulo Jos{\'e} Alves Felizola and Yasuhiro Nakamura and Fumitoshi Satoh and Ryo Morimoto and Kumi Kikuchi and Tomohiro Nakamura and Atsushi Hozawa and Lin Wang and Yoshiaki Onodera and Kazue Ise and Keely May McNamara and Sanae Midorikawa and Shinichi Suzuki and Hironobu Sasano},
  journal={Molecular and Cellular Endocrinology},
PCP4: a regulator of aldosterone synthesis in human adrenocortical tissues.
PCP4 immunoreactivity was predominantly detected in APA and in the zona glomerulosa of NA and IHA and indicates that PCP4 is a regulator of aldosterone production in normal, hyperplastic, and neoplastic human adrenocortical cells.
Metallothionein-3 (MT-3) in the Human Adrenal Cortex and its Disorders
The presence of MT-3 in the ZG of NA, IHA, and AAG, as well as APA may imply a role in the pathophysiology of aldosterone-producing tissues.
Activating transcription factor 3 (ATF3) in the human adrenal cortex: its possible involvement in aldosterone biosynthesis.
The results suggest that ATF3 is a downstream target of SRC and CaMKII signaling, and may be involved in adrenocortical aldosterone synthesis.
Voltage-gated calcium channels in the human adrenal and primary aldosteronism
Effect of blockade of mGluR5 on stress hormone release and its gene expression in the adrenal gland.
Pharmacological blockade of mGluR5 has a modest influence on the hypothalamic-pituitary-adrenocortical axis, as reflected in adrenal hypertrophy and increased corticosterone concentrations.
Adrenal CYP11B1/2 expression in primary aldosteronism: Immunohistochemical analysis using novel monoclonal antibodies
3β-hydroxysteroid dehydrogenase isoforms in human aldosterone-producing adenoma
Guanosine triphosphate can directly regulate cortisol production by activating Ca(2+)-messenger systems in bovine adrenal fasciculata cells.
GTP-induced steroid secretion in bovine adrenal fasciculata cells is under paracrine or autocrine control, suggesting that GTP activates cortisol biosynthesis possibly via a protein kinase C-dependent pathway.


Characterization of Serotonin4 Receptors in Adrenocortical Aldosterone-Producing Adenomas: In Vivo and in Vitro Studies
In two patients, a marked decrease in the plasma aldosterone response to cisapride was observed after surgical removal of the tumor, and the effects of 5- HT and selective 5-HT4 ligands on ald testosterone production from aldosteronoma tissues were studied in vitro using a perifusion system technique.
G-protein-coupled receptors in aldosterone-producing adenomas: a potential cause of hyperaldosteronism.
A potential role of altered GPCR expression in many cases of PA is suggested and candidate GPCRs are provided for further study.
Angiotensin-II acute regulation of rapid response genes in human, bovine, and rat adrenocortical cells.
The presence of adrenal cell common genes in such distinct cell models strengthens the hypothesis that these genes are regulators of aldosterone production.
Role of angiotensin II-induced rapid response genes in the regulation of enzymes needed for aldosterone synthesis.
Results suggest that Ang II binding to the AT1R increases activity of PKC, CaMK, and SRC, which act to increase expression of the family of NGFI-B genes as well as CYP11B2.
Hormonal regulation of angiotensin II type 1 receptor expression and AT1-R mRNA levels in human adrenocortical cells.
Human adrenocortical H295R cells express AII receptors which are predominantly of the AT1 but not AT2 subclass, and control of AT1-R expression appears to be complex, being achieved at least in part through control of the level of AT 1-R mRNA by multiple independent signaling pathways includingprotein kinase A, protein kinase C and Ca2+.
Differential expression of AMPA glutamate receptor mRNAs in the rat adrenal gland
Metabotropic glutamate receptor type 4 is involved in autoinhibitory cascade for glucagon secretion by alpha-cells of islet of Langerhans.
Results indicate that alpha- and F cells express functional mGluR4, and its stimulation inhibits secretion of glucagon through an inhibitory cAMP cascade, indicating that L-glutamate may directly interact with alpha-cells and inhibit glucagon secretion.
Angiotensin II and Cyclic Adenosine 3',5'-Monophosphate Induce Human Steroidogenic Acute Regulatory Protein Transcription through a Common Steroidogenic Factor-1 Element1.
It is shown that StAR steady state messenger RNA levels are increased by Bt2cAMP and AII, but not by K+ or 12-O-tetradecanoylphorbol-13-acetate, treatment of H295R cells.
Hormonal and developmental regulation of the steroidogenic acute regulatory protein.
Evidence that StAR is the key mediator of the acute induction of steroidogenesis is strengthened and new insights into the mechanisms by which trophic hormones activate steroidogenesis in steroidogenic cells are provided.