Glutamate receptors and the regulation of steroidogenesis in the human adrenal gland: The metabotropic pathway

@article{Felizola2014GlutamateRA,
  title={Glutamate receptors and the regulation of steroidogenesis in the human adrenal gland: The metabotropic pathway},
  author={Saulo Jos{\'e} Alves Felizola and Yasuhiro Nakamura and Fumitoshi Satoh and Ryo Morimoto and Kumi Kikuchi and Tomohiro Nakamura and Atsushi Hozawa and Lin Wang and Yoshiaki Onodera and Kazue Ise and Keely May McNamara and Sanae Midorikawa and Shinichi Suzuki and Hironobu Sasano},
  journal={Molecular and Cellular Endocrinology},
  year={2014},
  volume={382},
  pages={170-177}
}
PCP4: a regulator of aldosterone synthesis in human adrenocortical tissues.
TLDR
PCP4 immunoreactivity was predominantly detected in APA and in the zona glomerulosa of NA and IHA and indicates that PCP4 is a regulator of aldosterone production in normal, hyperplastic, and neoplastic human adrenocortical cells.
Metallothionein-3 (MT-3) in the Human Adrenal Cortex and its Disorders
TLDR
The presence of MT-3 in the ZG of NA, IHA, and AAG, as well as APA may imply a role in the pathophysiology of aldosterone-producing tissues.
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TLDR
The results suggest that ATF3 is a downstream target of SRC and CaMKII signaling, and may be involved in adrenocortical aldosterone synthesis.
Voltage-gated calcium channels in the human adrenal and primary aldosteronism
Effect of blockade of mGluR5 on stress hormone release and its gene expression in the adrenal gland.
TLDR
Pharmacological blockade of mGluR5 has a modest influence on the hypothalamic-pituitary-adrenocortical axis, as reflected in adrenal hypertrophy and increased corticosterone concentrations.
Adrenal CYP11B1/2 expression in primary aldosteronism: Immunohistochemical analysis using novel monoclonal antibodies
3β-hydroxysteroid dehydrogenase isoforms in human aldosterone-producing adenoma
Guanosine triphosphate can directly regulate cortisol production by activating Ca(2+)-messenger systems in bovine adrenal fasciculata cells.
TLDR
GTP-induced steroid secretion in bovine adrenal fasciculata cells is under paracrine or autocrine control, suggesting that GTP activates cortisol biosynthesis possibly via a protein kinase C-dependent pathway.
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