Glutamate receptors and the regulation of steroidogenesis in the human adrenal gland: The metabotropic pathway

  title={Glutamate receptors and the regulation of steroidogenesis in the human adrenal gland: The metabotropic pathway},
  author={Saulo J. A. Felizola and Y. Nakamura and F. Satoh and R. Morimoto and H. Sasano},
  journal={Molecular and Cellular Endocrinology},
  • Saulo J. A. Felizola, Y. Nakamura, +2 authors H. Sasano
  • Published 2014
  • Chemistry, Medicine
  • Molecular and Cellular Endocrinology
  • BACKGROUND l-glutamate is a major excitatory neurotransmitter in the mammalian brain. Glutamate receptors have been reported in the rat adrenal cortex and in human aldosterone-producing adenomas (APA). However, details regarding the expression levels and functions of these receptors in human adrenocortical tissues remain unknown. METHODS The mRNA levels of glutamate receptors were evaluated by qPCR in: 12 normal adrenal cortex (NAC), 11 APA, and 12 cortisol-producing adenoma (CPA) tissues… CONTINUE READING
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