Glutamate receptor subunit GluA1 is necessary for long-term potentiation and synapse unsilencing, but not long-term depression in mouse hippocampus.

@article{Selcher2012GlutamateRS,
  title={Glutamate receptor subunit GluA1 is necessary for long-term potentiation and synapse unsilencing, but not long-term depression in mouse hippocampus.},
  author={Joel C. Selcher and Weifeng Xu and Jesse E Hanson and Robert C Malenka and Daniel V. Madison},
  journal={Brain research},
  year={2012},
  volume={1435},
  pages={8-14}
}
Receptor subunit composition is believed to play a major role in the synaptic trafficking of AMPA receptors (AMPARs), and thus in activity-dependent synaptic plasticity. To isolate a physiological role of GluA1-containing AMPARs in area CA3 of the hippocampus, pair recordings were performed in organotypic hippocampal slices taken from genetically modified mice lacking the GluA1 subunit. We report here that long-term potentiation (LTP) is impaired not only at active but also at silent synapses… CONTINUE READING
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