Glutamate receptor pathology is present in the hippocampus following repeated sub-lethal soman exposure in the absence of spatial memory deficits.

@article{Johnson2008GlutamateRP,
  title={Glutamate receptor pathology is present in the hippocampus following repeated sub-lethal soman exposure in the absence of spatial memory deficits.},
  author={Erik A. Johnson and Kelly S Daugherty and Sarah J Gallagher and Anita V. Moran and Suzanne M. DeFord},
  journal={Neurotoxicology},
  year={2008},
  volume={29 1},
  pages={73-80}
}
Much is still unknown about the long-term effects of repeated, sub-lethal exposure to organophosphorus (OP) nerve agents, such as soman (GD), on learning and memory tasks and related protein expression in the hippocampus. In the present study, guinea pigs were exposed to sub-lethal doses of GD for 10 days and cognitive performance assessed using the Morris water maze (MWM) up to 88 days post-exposure to investigate spatial learning. Additionally, hippocampal lysates were probed for cytoskeletal… CONTINUE READING

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