Glutamate receptor ion channel properties predict vulnerability to cytotoxicity in a transfected nonneuronal cell line.

@article{Raymond1996GlutamateRI,
  title={Glutamate receptor ion channel properties predict vulnerability to cytotoxicity in a transfected nonneuronal cell line.},
  author={Lynn A Raymond and Ali Moshaver and Whittemore G. Tingley and Richard L. Huganir},
  journal={Molecular and cellular neurosciences},
  year={1996},
  volume={7 2},
  pages={102-15}
}
Excessive activation of glutamate receptors is thought to play a critical role in neuronal excitotoxicity. To compare the cytotoxic potential of different glutamate receptor subtypes and correlate receptor biophysical properties with cytotoxicity, we have expressed recombinant receptors in human embryonic kidney 293 (HEK-293) cells. Survival of transfected cells was analyzed under conditions of defined agonist concentration and exposure time. For HEK-293 cells transfected with N-methyl-D… CONTINUE READING

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