Glutamate receptor involvement in dentate granule cell epileptiform activity evoked by mossy fiber stimulation.

@article{Okazaki2001GlutamateRI,
  title={Glutamate receptor involvement in dentate granule cell epileptiform activity evoked by mossy fiber stimulation.},
  author={Maxine M. Okazaki and J. Victor Nadler},
  journal={Brain research},
  year={2001},
  volume={915 1},
  pages={58-69}
}
In many persons with temporal lobe epilepsy, dentate granule cells form an interconnected synaptic network. This recurrent mossy fiber circuit mediates reverberating excitation that may facilitate seizure propagation by synchronizing granule cell discharge. The involvement of specific glutamate receptors in granule cell epileptiform activity evoked by stimulating the mossy fibers was investigated with use of rat hippocampal slices superfused with bicuculline, with or without increasing [K+](o… CONTINUE READING
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