Glutamate receptor-induced toxicity in neostriatal cells

  title={Glutamate receptor-induced toxicity in neostriatal cells},
  author={Christopher S Colwell and Michael S Levine},
  journal={Brain Research},
Infrared differential interference contrast (IR DIC) videomicroscopy was used to measure and characterize cell swelling induced by activation of glutamate receptors (GluR) in a neostriatal brain slice preparation. This swelling is, in many cases, a prelude to necrotic cell death. Activation of N-methyl-D-aspartate (NMDA) and non-NMDA ionotropic GluRs caused cell swelling. The concentration-response relationships and the time courses of the onset of agonist-induced swelling were very similar for… CONTINUE READING


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