Glutamate receptor dynamics organizing synapse formation in vivo

  title={Glutamate receptor dynamics organizing synapse formation in vivo},
  author={Tobias M. Rasse and Wernher Fouquet and Andreas Schmid and Robert J Kittel and Sara Mertel and Carola B. Sigrist and Manuela Schmidt and Asja Guzman and Carlos Merino and Gang Qin and Christine Quentin and Frank Madeo and Manfred Heckmann and Stephan J. Sigrist},
  journal={Nature Neuroscience},
Insight into how glutamatergic synapses form in vivo is important for understanding developmental and experience-triggered changes of excitatory circuits. Here, we imaged postsynaptic densities (PSDs) expressing a functional, GFP-tagged glutamate receptor subunit (GluR-IIAGFP) at neuromuscular junctions of Drosophila melanogaster larvae for several days in vivo. New PSDs, associated with functional and structural presynaptic markers, formed independently of existing synapses and grew… CONTINUE READING
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