Glutamate receptor antagonists in cerebral ischaemia.

  title={Glutamate receptor antagonists in cerebral ischaemia.},
  author={J Mcculloch},
  journal={Journal of neural transmission. Supplementum},
  • J Mcculloch
  • Published 1994 in Journal of neural transmission. Supplementum
Glutamate mediated neuronal death has been implicated in every human neurodegenerative disease, but cerebral ischaemia is the area where the modulation of excitotoxicity is closest to providing a new therapeutic avenue. In cerebral ischaemia there is a marked, immediate increase in the extracellular concentration of glutamate, irrespective of the nature and primary cause of the ischaemic episode. Elevations in the extracellular concentrations of glutamate lead to excessive activation of the… CONTINUE READING
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