Glutamate receptor agonists: stereochemical aspects.

  title={Glutamate receptor agonists: stereochemical aspects.},
  author={Stine Byskov Vogensen and Jeremy R. Greenwood and Lennart Bunch and Rasmus Pr{\ae}torius Clausen},
  journal={Current topics in medicinal chemistry},
  volume={11 7},
The neurotransmitter (S)-glutamate [(S)-Glu] is responsible for most of the excitatory neurotransmission in the central nervous system. The effect of (S)-Glu is mediated by both ionotropic and metabotropic receptors. Glutamate receptor agonists are generally α-amino acids with one or more stereogenic centers due to strict requirements in the agonist binding… CONTINUE READING