Glutamate receptor activation induces carrier mediated release of endogenous GABA from rat striatal slices

@article{Wang2005GlutamateRA,
  title={Glutamate receptor activation induces carrier mediated release of endogenous GABA from rat striatal slices},
  author={J. Wang and Gy{\"o}rgy Lonart and K. M. Johnson},
  journal={Journal of Neural Transmission},
  year={2005},
  volume={103},
  pages={31-43}
}
SummaryThe regulation of striatonigral and striatopallidal GABAergic neurons by glutamatergic afferents is thought to play a critical role in normal basal ganglia function. Here we report that in striatal slices about 17% of K+-induced endogenous GABA release was Ca2+-independent and this could be blocked by a GABA transport inhibitor. Activation of N-methyl-D-aspartate (NMDA)- and quisqualate-sensitive receptors induced endogenous GABA efflux only in the presence of a GABA transaminase… 

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