Glutamate receptor activation induces carrier mediated release of endogenous GABA from rat striatal slices

  title={Glutamate receptor activation induces carrier mediated release of endogenous GABA from rat striatal slices},
  author={J. Wang and Gy{\"o}rgy Lonart and K. M. Johnson},
  journal={Journal of Neural Transmission},
SummaryThe regulation of striatonigral and striatopallidal GABAergic neurons by glutamatergic afferents is thought to play a critical role in normal basal ganglia function. Here we report that in striatal slices about 17% of K+-induced endogenous GABA release was Ca2+-independent and this could be blocked by a GABA transport inhibitor. Activation of N-methyl-D-aspartate (NMDA)- and quisqualate-sensitive receptors induced endogenous GABA efflux only in the presence of a GABA transaminase… 

Modulatory effects of activation of metabotropic glutamate receptors on GABAergic circuits in the mouse cortex.

The effect of mGluR activation on GABAergic inputs in cortex was found to reduce the amplitude of the evoked inhibitory postsynaptic currents, and it was concluded this reduction was due to activation of presynaptic mGLURs.

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The presence of NMDA receptors on dopaminergic nerve terminals that mediate the ability of L-glutamate to release DA is demonstrated and an additional mechanism by which information from the nigrostriatal and corticostriatal pathways may be integrated is suggested.

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The differential localization of distinct muscarinic receptor subtypes on terminals releasing the major inhibitory and excitatory transmitters of the brain could be exploited therapeutically in some movement disorders and Alzheimer disease.

Presynaptic depression of synaptic transmission mediated by activation of metabotropic glutamate receptors in rat neocortex

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    The Journal of neuroscience : the official journal of the Society for Neuroscience
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Findings indicate that a specific mGluR subtype(s) may modulate both excitatory and inhibitory synaptic transmission in the adult rat neocortical brain slices via a presynaptic reduction of transmitter release.

Phencyclidine analogues inhibit NMDA-stimulated [3H]GABA release from cultured cortex neurons.