Glutamate participates in the peripheral modulation of thermal hyperalgesia in rats.

@article{Jackson1995GlutamatePI,
  title={Glutamate participates in the peripheral modulation of thermal hyperalgesia in rats.},
  author={Douglass L. Jackson and Caroline Graff and Jenny D Richardson and Kenneth M Hargreaves},
  journal={European journal of pharmacology},
  year={1995},
  volume={284 3},
  pages={321-5}
}
While the effects of excitatory amino acids have been well characterized in the central nervous system, relatively little is known about their possible modulation of elements responsible for hyperalgesia within peripheral tissue. The presented experiments demonstrate that the intraplantar (i.pl.) injection of L-glutamate (30 nmol) evokes a thermal hyperalgesic response in the paw withdrawal latencies of normal rats which is stereospecific. In addition, the i.pl. injection of either the non… CONTINUE READING

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