Glutamate neurotoxicity in cortical cell culture

@inproceedings{Choi1987GlutamateNI,
  title={Glutamate neurotoxicity in cortical cell culture},
  author={Dennis W. Choi and Margaret Maulucci-Gedde and Arnold R. Kriegstein},
  booktitle={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1987}
}
The central neurotoxicity of the excitatory amino acid neurotransmitter glutamate has been postulated to participate in the pathogenesis of the neuronal cell loss associated with several neurological disease states, but the complexity of the intact nervous system has impeded detailed analysis of the phenomenon. In the present study, glutamate neurotoxicity was studied with novel precision in dissociated cell cultures prepared from the fetal mouse neocortex. Brief exposure to glutamate was found… Expand
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  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1988
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Zinc produced a concentration-dependent reduction in glutamate- induced neuronal injury in a fashion similar to that seen with NMDA, but less effectively, and paradoxically increased the glutamate-induced destruction of nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d)-containing neurons. Expand
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