Glutamate metabotropic receptors as targets for drug therapy in epilepsy.

  title={Glutamate metabotropic receptors as targets for drug therapy in epilepsy.},
  author={Randal X. Moldrich and Astrid G Chapman and Giovambattista De Sarro and Brian S. Meldrum},
  journal={European journal of pharmacology},
  volume={476 1-2},
Metabotropic glutamate (mGlu) receptors have multiple actions on neuronal excitability through G-protein-linked modifications of enzymes and ion channels. They act presynaptically to modify glutamatergic and gamma-aminobutyric acid (GABA)-ergic transmission and can contribute to long-term changes in synaptic function. The recent identification of subtype-selective agonists and antagonists has permitted evaluation of mGlu receptors as potential targets in the treatment of epilepsy. Agonists… CONTINUE READING


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