Glutamate levels and activity of the T cell voltage-gated potassium Kv1.3 channel in patients with systemic lupus erythematosus.

@article{Poulopoulou2008GlutamateLA,
  title={Glutamate levels and activity of the T cell voltage-gated potassium Kv1.3 channel in patients with systemic lupus erythematosus.},
  author={Cornelia Poulopoulou and Z Papadopoulou-Daifoti and Alexandros Hatzimanolis and Kalliopi Fragiadaki and Alexia Polissidis and E Anderzanova and Panagiota Davaki and Christina G. Katsiari and Petros P. Sfikakis},
  journal={Arthritis and rheumatism},
  year={2008},
  volume={58 5},
  pages={
          1445-50
        }
}
OBJECTIVE Alterations in glutamate homeostasis and Kv1.3 voltage-gated potassium channel function have been independently associated with T cell dysfunction, whereas selective blockade of Kv1.3 channels inhibits T cell activation and improves T cell-mediated manifestations in animal models of autoimmunity. Because low extracellular glutamate concentrations enhance the activity of this channel in normal T cells ex vivo, we undertook this study to examine serum glutamate concentrations and Kv1.3… CONTINUE READING

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