Glutamate induces release of glutathione from cultured rat astrocytes--a possible neuroprotective mechanism?

@article{Frade2008GlutamateIR,
  title={Glutamate induces release of glutathione from cultured rat astrocytes--a possible neuroprotective mechanism?},
  author={Jo{\~a}o Graça Frade and Simon Pope and Maike Schmidt and Ralf Dringen and Rui Barbosa and Jennifer Pocock and Jo{\~a}o Laranjinha and Simon J H Heales},
  journal={Journal of neurochemistry},
  year={2008},
  volume={105 4},
  pages={1144-52}
}
Glutamate is the major excitatory amino acid of the mammalian brain but can be toxic to neurones if its extracellular levels are not tightly controlled. Astrocytes have a key role in the protection of neurones from glutamate toxicity, through regulation of extracellular glutamate levels via glutamate transporters and metabolic and antioxidant support. In this study, we report that cultures of rat astrocytes incubated with high extracellular glutamate (5 mM) exhibit a twofold increase in the… CONTINUE READING