Glutamate induces neurotrophic factor production from microglia via protein kinase C pathway.

@article{Liang2010GlutamateIN,
  title={Glutamate induces neurotrophic factor production from microglia via protein kinase C pathway.},
  author={Jianfeng Liang and Hideyuki Takeuchi and Shijie Jin and Mariko Noda and Hua Li and Yukiko Doi and Jun Kawanokuchi and Yoshifumi Sonobe and Tetsuya Mizuno and Akio Suzumura},
  journal={Brain research},
  year={2010},
  volume={1322},
  pages={8-23}
}
Microglia are intrinsic immune cells in the central nervous system and play key roles in the pathogenesis of various central nervous system disorders. Microglia have been shown to attack damaged neurons by secreting a variety of neurotoxic factors including inflammatory cytokines, reactive oxygen species and glutamate. On the other hand, they can produce neurotrophic factors (NTFs) which support neuronal survival and growth. However, the precise mechanism that regulates microglial NTF… CONTINUE READING