Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function

@article{Ankarcrona1995GlutamateinducedND,
  title={Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function},
  author={M. Ankarcrona and J. Dypbukt and E. Bonfoco and B. Zhivotovsky and S. Orrenius and S. Lipton and P. Nicotera},
  journal={Neuron},
  year={1995},
  volume={15},
  pages={961-973}
}
During ischemic brain injury, glutamate accumulation leads to overstimulation of postsynaptic glutamate receptors with intracellular Ca2+ overload and neuronal cell death. Here we show that glutamate can induce either early necrosis or delayed apoptosis in cultures of cerebellar granule cells. During and shortly after exposure to glutamate, a subpopulation of neurons died by necrosis. In these cells, mitochondrial membrane potential collapsed, nuclei swelled, and intracellular debris were… Expand
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