Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function

@article{Ankarcrona1995GlutamateinducedND,
  title={Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function},
  author={Maria Ankarcrona and Jeannette M. Dypbukt and Emanuela Bonfoco and Boris Zhivotovsky and Sten Orrenius and Stuart Lipton and Pierluigi Nicotera},
  journal={Neuron},
  year={1995},
  volume={15},
  pages={961-973}
}
During ischemic brain injury, glutamate accumulation leads to overstimulation of postsynaptic glutamate receptors with intracellular Ca2+ overload and neuronal cell death. Here we show that glutamate can induce either early necrosis or delayed apoptosis in cultures of cerebellar granule cells. During and shortly after exposure to glutamate, a subpopulation of neurons died by necrosis. In these cells, mitochondrial membrane potential collapsed, nuclei swelled, and intracellular debris were… CONTINUE READING
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During and shortly after exposure to glutamate , a subpopulation of neurons died by necrosis .
During and shortly after exposure to glutamate , a subpopulation of neurons died by necrosis .
Glutamate - induced neuronal death : A succession of necrosis or apoptosis depending on mitochondrial function .
Glutamate - induced neuronal death : A succession of necrosis or apoptosis depending on mitochondrial function .
Glutamate - induced neuronal death : A succession of necrosis or apoptosis depending on mitochondrial function .
Glutamate - induced neuronal death : A succession of necrosis or apoptosis depending on mitochondrial function .
Glutamate - induced neuronal death : A succession of necrosis or apoptosis depending on mitochondrial function .
Glutamate - induced neuronal death : A succession of necrosis or apoptosis depending on mitochondrial function .
During ischemic brain injury , glutamate accumulation leads to overstimulation of postsynaptic glutamate receptors with intracellular Ca2 + overload and neuronal cell death .
During ischemic brain injury , glutamate accumulation leads to overstimulation of postsynaptic glutamate receptors with intracellular Ca2 + overload and neuronal cell death .
Glutamate - induced neuronal death : A succession of necrosis or apoptosis depending on mitochondrial function .
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