Glutamate-induced long-term potentiation of the frequency of miniature synaptic currents in cultured hippocampal neurons

@article{Malgaroli1992GlutamateinducedLP,
  title={Glutamate-induced long-term potentiation of the frequency of miniature synaptic currents in cultured hippocampal neurons},
  author={Antonio Malgaroli and Richard W. Tsien},
  journal={Nature},
  year={1992},
  volume={357},
  pages={134-139}
}
Glutamate application at synapses between hippocampal neurons in culture produces long-term potentiation of the frequency of spontaneous miniature synaptic currents, together with long-term potentiation of evoked synaptic currents. The mini frequency potentiation is initiated postsynaptically and requires activity of NMDA receptors. Although the frequency of unitary quanta! responses increases strongly, their amplitude remains little changed with potentiation. Tests of postsynaptic… CONTINUE READING