Glutamate increases the [Ca2+]i but stimulates Ca(2+)-independent release of [3H]GABA in cultured chick retina cells.

@article{Duarte1993GlutamateIT,
  title={Glutamate increases the [Ca2+]i but stimulates Ca(2+)-independent release of [3H]GABA in cultured chick retina cells.},
  author={Carlos B Duarte and Ildete L. Ferreira and Paulo J. Santos and Catarina Resende de Oliveira and Ars{\'e}lio Pato Carvalho},
  journal={Brain research},
  year={1993},
  volume={611 1},
  pages={130-8}
}
The effect of glutamate on [Ca2+]i and on [3H] gamma-aminobutyric acid (GABA) release was studied on cultured chick embryonic retina cells. It was observed that glutamate (100 microM) increases the [Ca2+]i by Ca2+ influx through Ca2+ channels sensitive to nitrendipine, but not to omega-conotoxin GVIA (omega-Cg Tx) (50%), and by other channels insensitive to either Ca2+ channel blocker. Mobilization of Ca2+ by glutamate required the presence of external Na+, suggesting that Na+ mobilization… CONTINUE READING
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