Glutamate in the nucleus of the solitary tract activates both ionotropic and metabotropic glutamate receptors.

@article{Foley1998GlutamateIT,
  title={Glutamate in the nucleus of the solitary tract activates both ionotropic and metabotropic glutamate receptors.},
  author={C. Michael Foley and Julia A Moffitt and Meredith Hay and Eileen M Hasser},
  journal={The American journal of physiology},
  year={1998},
  volume={275 6 Pt 2},
  pages={R1858-66}
}
Glutamate is the proposed neurotransmitter of baroreceptor afferents at the level of the nucleus of the solitary tract (NTS). Blockade of ionotropic glutamate receptors with kynurenic acid blocks the arterial baroreflex but, paradoxically, does not abolish the response to exogenous glutamate. This study tested the hypothesis that exogenous glutamate in the NTS activates both ionotropic and metabotropic glutamate receptors (mGluRs). In urethan-anesthetized rats, unilateral microinjections of… CONTINUE READING

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