Glutamate impairs neuronal calcium extrusion while reducing sodium gradient

@article{Kiedrowski1994GlutamateIN,
  title={Glutamate impairs neuronal calcium extrusion while reducing sodium gradient},
  author={L. Kiedrowski and G. Brooker and E. Costa and J. Wroblewski},
  journal={Neuron},
  year={1994},
  volume={12},
  pages={295-300}
}
The rate of decrease of neuronal [Ca2+]i after an elevation induced by a glutamate pulse is much slower than that after a comparable [Ca2+]i elevation induced by a K+ depolarization. To investigate whether the [Na+]i increase taking place during the glutamate pulse reduces the rate of Ca2+ extrusion, we monitored simultaneously [Na+]i and [Ca2+]i during a K+ depolarization and a glutamate pulse lasting 1 min. The K+ depolarization evoked only a transient increase of [Na+]i from 4 mM to 13 mM… Expand
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