Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics.

@article{Wolstenholme2005GlutamategatedCC,
  title={Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics.},
  author={Adrian J Wolstenholme and Adrian T. Rogers},
  journal={Parasitology},
  year={2005},
  volume={131 Suppl},
  pages={
          S85-95
        }
}
The macrocyclic lactones are the biggest selling and arguably most effective anthelmintics currently available. They are good substrates for the P-glycoproteins, which might explain their selective toxicity for parasites over their vertebrate hosts. Changes in the expression of these pumps have been implicated in resistance to the macrocyclic lactones, but it is clear that they exert their anthelmintic effects by binding to glutamate-gated chloride channels expressed on nematode neurones and… CONTINUE READING

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