Glutamate exocytosis from astrocytes controls synaptic strength

  title={Glutamate exocytosis from astrocytes controls synaptic strength},
  author={P. Jourdain and Linda H Bergersen and Khaleel Bhaukaurally and Paola Bezzi and Mirko Santello and Maria Domercq and Carlos Matute and Fiorella Tonello and Vidar Gundersen and Andrea Volterra},
  journal={Nature Neuroscience},
The release of transmitters from glia influences synaptic functions. The modalities and physiological functions of glial release are poorly understood. Here we show that glutamate exocytosis from astrocytes of the rat hippocampal dentate molecular layer enhances synaptic strength at excitatory synapses between perforant path afferents and granule cells. The effect is mediated by ifenprodil-sensitive NMDA ionotropic glutamate receptors and involves an increase of transmitter release at the… CONTINUE READING
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