Glutamate enhances survival and proliferation of neural progenitors derived from the subventricular zone.

@article{Brazel2005GlutamateES,
  title={Glutamate enhances survival and proliferation of neural progenitors derived from the subventricular zone.},
  author={Christine Y Brazel and Joseph L. Nu{\~n}ez and Zhengang Yang and Steven W Levison},
  journal={Neuroscience},
  year={2005},
  volume={131 1},
  pages={55-65}
}
Extracellular glutamate levels increase as a consequence of perinatal hypoxia/ischemia, causing the death of neurons and oligodendrocytes. Precursors in the subventricular zone (SVZ) also die following perinatal hypoxia/ischemia; therefore we hypothesized that glutamate would stimulate the death of neural precursors. Here we demonstrate using calcium imaging that SVZ derived neural stem/progenitor cells respond to both ionotropic and metabotropic excitatory amino acids. Therefore, we tested the… CONTINUE READING
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Selective vulnerability of late oligodendrocyte progenitors to hypoxia-ischemia.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2002
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