Glutamate dehydrogenase in human brain: regional distribution and properties.

  title={Glutamate dehydrogenase in human brain: regional distribution and properties.},
  author={Alessandro Filla and Giuseppe De Michele and Vincenzo Brescia Morra and Vincenzo Palma and A Di Lauro and G di Geronimo and Giuseppe Campanella},
  journal={Journal of neurochemistry},
  volume={46 2},
Glutamate dehydrogenase (GDH) activity was studied in 17 regions of six human brains. Duration and conditions of the postmortem period did not affect enzyme activity. Specific activity ranged between 103 and 377 nmoles/min/mg protein at 25 degrees C and it was 10-fold higher than that found in leukocytes. Apart from exclusively white matter regions (corpus callosum and centrum ovale), there was a moderate regional distribution (2.5-fold variation), with highest values in the inferior olive and… CONTINUE READING