Glutamate dehydrogenase, the marker protein of Plasmodium falciparum--cloning, expression and characterization of the malarial enzyme.

@article{Wagner1998GlutamateDT,
  title={Glutamate dehydrogenase, the marker protein of Plasmodium falciparum--cloning, expression and characterization of the malarial enzyme.},
  author={Josef Wagner and H. L{\"u}demann and Philipp F{\"a}rber and Friedrich Lottspeich and R Luise Krauth-Siegel},
  journal={European journal of biochemistry},
  year={1998},
  volume={258 2},
  pages={
          813-9
        }
}
The gene of an NADP+-specific glutamate dehydrogenase was cloned from Plasmodium falciparum, the causative agent of tropical malaria. Southern-blot analysis indicates a single-copy gene. The gene encodes a protein with 470 residues which has 50% of all residues identical with those of the glutamate dehydrogenases from other low eukaryotes and eubacteria. In contrast, the sequence identity with the human enzyme is marginal, which underlines the long evolutionary distance between parasite and… CONTINUE READING

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