Glutamate controls tPA recycling by astrocytes, which in turn influences glutamatergic signals.


Tissue-type plasminogen activator (tPA) regulates physiological processes in the brain, such as learning and memory, and plays a critical role in neuronal survival and neuroinflammation in pathological conditions. Here we demonstrate, by combining mouse in vitro and in vivo data, that tPA is an important element of the cross talk between neurons and… (More)
DOI: 10.1523/JNEUROSCI.5296-11.2012


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