Glutamate causes a loss in human cerebral endothelial barrier integrity through activation of NMDA receptor.

@article{Sharp2003GlutamateCA,
  title={Glutamate causes a loss in human cerebral endothelial barrier integrity through activation of NMDA receptor.},
  author={Christopher D. Sharp and Ian Neil Hines and Jeff Houghton and Anne Warren and T. Haller Jackson and Ajay Jawahar and Ashis Nanda and John W. Elrod and Ai-hua Long and Andrew Chi and Alireza Minagar and Jonathan S. Alexander},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2003},
  volume={285 6},
  pages={H2592-8}
}
l-Glutamate is a major excitatory neurotransmitter that binds ionotropic and metabotropic glutamate receptors. Cerebral endothelial cells from many species have been shown to express several forms of glutamate receptors; however, human cerebral endothelial cells have not been shown to express either the N-methyl-D-aspartate (NMDA) receptor message or protein. This study provides evidence that human cerebral endothelial cells express the message and protein for NMDA receptors. Human cerebral… CONTINUE READING

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